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KMID : 0380620220540020209
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 2 p.209 ~ p.217
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Antimicrobial effect of Enterococcus faecalis BMSE-HMP005 isolated from human breast milk against multidrug-resistant bacteria
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Lee Jeong-Eun
Kim Soo-Bin
Yu Du-Na
Jo So-Yeon
Kim Ae-Jung
Kook Moo-Chang
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Abstract
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In this study, Enterococcus faecalis BMSE-HMP005 isolated from human breast milk demonstrated antimicrobial effects against multidrug-resistant (MDR) bacterial strains. The bacteriocin produced by E. faecalis BMSE-HMP005 was fractionated using reverse-phase high-performance liquid chromatography. This fraction showed antimicrobial effects against both gram-positive and gram-negative MDR bacteria. No hemolytic reactions were observed. E. faecalis BMSEHMP005 was resistant to vancomycin; however, kanamycin, ampicillin, and erythromycin showed minimum inhibitory concentrations that were lower than the acceptable range provided by the European Food Safety Authority. For artificial gastric juice and bile acid, the survival rates were 98.67% and 95.70%, respectively. These results show the potential utility of E. faecalis BMSE-HMP005 as a probiotic with remarkable antimicrobial effects against MDR bacteria.
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KEYWORD
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human breast milk, Enterococcus faecalis, multidrug-resistant bacteria, lactic acid bacteria, antimicrobial effect
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